Expression and significance of NDRG2, C-MYC, and KI67 in gastric cancer and adjacent tissues

Objective: Expressions of NDRG2, C-MYC, and KI67 in gastric cancer (GC) and adjoining tissues were analyzed for their importance in the occurrence and development of the GC. Materials and Methods: Samples from GC and adjacent tissue of patients admitted to the Department of Surgery,XXX Hospital, China, from February 2018 to June 2021, were analyzed for the expression of NDRG2, C-MYC, and KI67 using immunohistochemistry. The association of NDRG2 and degrees of differentiation in gastric cancer were analyzed. Results: There were 41 GC patients in the study. The expression of NDRG2 was significantly lower ( P <0.05), and the C-MYC and KI67 were higher ( P <0.05) in GC versus adjacent tissues. NDRG2 expression varied significantly ( P <0.05) according to the degree differentiation in GC. The expression of KI67 was positively correlated with C-MYC (rs=0.409, P <0.05). Conclusions: There were significant differences in the expression of NDRG2 (low expression), and C-MYC, and KI67 (high expression) in gastric cancer and adjacent tissues. The degree of cancer differentiation was associated with expression of NDRG2 in GC tissue. NDRG2 expression was higher in para-carcinoma tissues and intestinal metaplasia glands.