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February 19, 2024PhytomedicineOpen Access

Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming

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Authors

CLCongyong LiuSun Yat-sen UniversityJHJungang HuangBoston Children's HospitalJQJunxiong QiuSun Yat-sen University

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Implication

Preclinical study demonstrates quercitrin improves cardiac ejection fraction and suppresses fibrosis in mice following myocardial infarction, highlighting therapeutic metabolic reprogramming.

Key Points

  • Quercitrin improves cardiac ejection fraction and mitigates adverse ventricular remodeling while significantly suppressing myocardial fibrosis in treated mice.
  • Flow cytometry shows expanded M2 macrophages with shifted metabolic reprogramming, featuring reduced glycolysis and enhanced aerobic phosphorylation.
  • Assessment using cardiac ultrasound and metabolomics demonstrates shifted arginine pathways following myocardial infarction; mouse model, further validation needed.

Cite This Study

Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e78822b6db6435876fb074https://doi.org/10.1016/j.phymed.2024.155467
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction2017 · 435 citations
  2. 2Quercitrin protects human bronchial epithelial cells from oxidative damage2022 · 9 citations