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February 19, 2024American Journal of Clinical NutritionOpen Access

Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn’s disease

Ben Nichols Anny Briola Michael Logan Jaroslav Havlík Anna Mascellani Konstantinos Gkikas Simon Milling Umer Zeeshan Ijaz Christopher Quince Vaios Svolos Richard K. Russell Richard Hansen Konstantinos Gerasimidis

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Abstract

Predicting response to exclusive enteral nutrition (EEN) in active Crohn's disease (CD) could lead to therapy personalization and pretreatment optimization.

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Cite This Study

Nichols et al. (2024) studied this question.

synapsesocial.com/papers/68e78948b6db6435876fb251 https://doi.org/10.1016/j.ajcnut.2023.12.027

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease2024 · 14 citations
2Metabolome remodeling with reverse-engineered exclusive enteral nutrition in children with active Crohn’s diseaseHuman Clinical Trial · 2026
3Treatment of Active Crohn’s Disease With Exclusive Enteral Nutrition Diminishes the Immunostimulatory Potential of Fecal Microbial Products2024 · 12 citations
4Characterization of Selected Metabolic and Immunologic Markers Following Exclusive Enteral Nutrition of Pediatric Crohn’s Disease Patientscohort · 2016 · 3 citations
5P1337 Gut Microbiome Remodeling by Biologics Combined with Exclusive Enteral Nutrition in Adult Crohn’s Disease: Microbial Signatures and Prediction of Non-remission over a 2-Year CohortRetrospective Study · 2026