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Objectives: Universal variability in the distribution of lymphomas has been reported for ages, and analyzing a large number of lymphoma cases is essential for proper insight into the disease. This study aims to obtain relative frequencies of lymphomas in India and compare them with different regions within the country, as well as with the rest of the world. Material and Methods: In our study, lymphoma data from two years (2019–2021) were studied, and based on morphology and immunohistochemistry (IHC), the lymphomas were subclassified according to the World Health Organization classification prevalent at the time. Results: The present study consisted of 2505 cases. Hodgkin lymphoma (HL) constituted 22.5%, while non-Hodgkin lymphomas (NHLs) constituted 77.5%. B-cell NHLs accounted for 85%, and T/NK cell neoplasms accounted for 15% of the NHL cases. The top two subtypes of NHL were diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. DLBCL-not otherwise specified was further subcategorized into the germinal center type and activated B-cell type by Hans algorithm, and cases with double-expressor phenotype were also documented. Conclusion: The frequency of some of these neoplasms was similar, whereas some showed variations when compared to other Indian, Asian, and Western literature. The high frequency of a few T/NK cell lymphomas, DLBCL and its subtypes and some rare B/T-NHLs are the salient features of this study.
Sarma et al. (Mon,) studied this question.