Up-regulation of the IL-1 signaling pathway enhances gene expression of transcription factors (Jun, Junb, Jund, Fos, and Fosb)

This paper focuses on the experiment method to find out the relationship between the IL-1 signaling pathway and the transcription factors; we use 5xFAD mice with targeted deletion of Bace-1 in microglia,We conjecture that the up-regulation of the IL-1 signaling pathway enhances gene expression of transcription factors (Jun, Junb, Jund, Fos, and Fosb), which probably increases the transition microglial signature. The specifically targeted inhibition of BACE-1 in microglia will likely offer a superior therapeutic alternative for improving AD outcomes, circumventing the safety concerns associated with neuronal deletion or global inhibition of BACE-1.