Association of MTNR1B rs10830963 C>G Polymorphism with the risk of Gestational Diabetes Mellitus: An Updated Meta-analysis

Gestational diabetes mellitus (GDM) is one of the metabolic disorders of pregnancy that result in shortand long-term adverse outcomes to both the mothers and her offspring.Among the factors linked to GDM susceptibility, genetic variations such as single nucleotide polymorphisms (SNPs) are the most implicated.Several case-control association studies have reported that the G allele of SNP rs10830963 in the melatonin receptor 1B (MTNR1B) is associated with higher GDM risk, however others reported insignificant associations.Previous meta-analyses also showed inconsistent findings.Herein, we performed a comprehensive literature search and meta-analysis to clarify the role of the SNP on GDM risk.Pooled odds ratios (ORs) with 95% CI were calculated to measure the strength of the association.Meta-analysis of the overall population using 11 eligible studies with a total of 4760 GDM cases and 5345 controls revealed significant association with the variant G allele and increased risk of GDM (CC vs. CG: OR = 1.28, 95% CI = 1.17-1.41,P < 0.001; CC vs. GG: OR = 1.92, 95% CI = 1.49-2.49,P < 0.001; C vs. G: OR = 1.30, 95% CI = 1.16-1.46,P < 0.001).In the subpopulation analysis, similar results were observed in Asians (CC vs. CG: OR = 1.26, 95% CI = 1.07-1.49,P = 0.005; CC vs. GG: OR = 1.66, 95% CI = 1.26-2.19,P < 0.001; C vs. G: OR = 1.30, 95% CI = 1.12-1.50,P < 0.001) with notably lower OR for CC vs GG.For the Euro-American population, higher ORs were noted for all the comparison models (CC vs. CG: OR = 1.40, 95% CI = 1.15-1.70,P = 0.005; CC vs. GG: OR = 2.84, 95% CI = 2.05-3.93,P < 0.001; C vs. G: OR = 1.37, 95% CI = 1.19-1.58,P < 0.001).Overall, the results suggest that the MTNR1B SNP rs10830963 is a risk factor for GDM across all populations with increased susceptibility observed among Euro-Americans.