Guideline of Management of Acute Smoke Inhalation Injury: Systematic Review and Meta-Analysis of Last 10 Years

Background: Inhalation injury-based respiratory failure is the main cause of death in patients with severe burns. In general, damage from smoke inhalation results in airway edema, inflammation and, subsequently, cellular debris, mucus, fibrin clots and polymorphonuclear leukocytes PNL combine to form casts that lead to ventilation/perfusion mismatch and poor oxygenation. Aim of the Work: This meta-analysis aims to review the Guideline of Management of Acute Smoke Inhalation Injury and discuss the different modalities and treatment.Materials and Methods: A comprehensive search of the literature to identify the Guideline of Management of Acute Smoke Inhalation Injury and discuss the different modalities and treatment. via electronic databases including OVID, Science Direct, Springer, Web of Science and Google Scholar. Initial search will carried out using keywords :“burns, “ARDS,” “adult respiratory distress syndrome ,” “extracorporeal membrane oxygenation” ,“ECMO,” “inhalation injury,” ,”smoke inhalation injury”, and “heparinized oxygen mask”, ”ECMO”.Results: All published articles were from 2013 to 2022 limited to human studies of different modalities will be analyzed and compared regarding the criteria of management.Conclusion: The care of patients with burn related inhalation injury remains highly challenging. Key topics include airway management, nebulized heparin, NAC, chest physiotherapy and ECMO effect.Early ambulation ,nebulized Heparin in combination with NAC and albuterol was associated with a reduction in the duration of mechanical and decrease mortality rate