Comparison of effects from gamma, e-beam and X-ray radiation on multilayer polymer films used in biopharmaceutical devices by chemometric treatment of spectroscopic data

The present study investigated the effects of gamma-ray, e-beam, and X-ray radiation on polymers in EVA/EVOH/EVA multilayer films. Spectroscopic methods, including FTIR and UV–Vis, were employed in conjunction with chemometric treatments such as PCA, SIMPLISMA treatments, and PLS models. The feasibility of dose prediction on multilayer film, given a known dose, is attainable across various irradiation technologies. Both gamma rays and X-rays exhibit comparable effects on the multilayer film, and it is feasible to anticipate the dose released on the film by utilizing UV–Vis spectra or infrared spectra for gamma rays or X-rays of a predetermined dose.