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February 16, 2024

Data from Backfilling Patients in Phase I Dose-Escalation Trials Using Bayesian Optimal Interval Design (BOIN)

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Authors

YZYixuan ZhaoChina Geological SurveyYYYing YuanThe University of Texas MD Anderson Cancer CenterEKEdward L. KornNational Cancer Institute

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Zhao et al. (2024) studied this question.

synapsesocial.com/papers/68e78e41b6db643587700397https://doi.org/10.1158/1078-0432.c.7077755
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  1. 1A robust Bayesian dose optimization design with backfill and randomization for phase I/II clinical trials2025 · 3 citations
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  3. 3A Bayesian Design with Efficient Backfilling and Expansion to Accelerate Phase I/II Trials Accommodating Late-Onset Competing Risk Outcomes2026
  4. 4Adoption of Bayesian Optimal Interval (BOIN) design in phase I oncology trials, trends, and challenges.2026
  5. 5Implementing and assessing Bayesian response-adaptive randomisation for backfilling in dose-finding trials2024 · 7 citations