Facile synthesis of aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring by microfluidic flow reaction chemistry

This study describes the development of a new and rapid synthesis procedure for performing the aryl and benzyl substituted 2-methylquinazolin-4(3H)-one ring cyclization reaction. We utilized a continuous-flow microfluidic reactor for the production of quinazolinone derivatives of a humanin peptide mimetic screening hit in a facile manner, offering a cleaner reaction profile, high yield, and quick scalability. Our results show the power of flow chemistry to this reaction and can be of general utility for synthesizing quinazolinone-containing intermediates and final products of industrial importance in a continuous and safe manner.