Endoscopic ultrasound-guided partial splenic embolization for hypersplenism: a novel alternative

Variceal bleeding and hypersplenism are two major complications of portal hypertension, for which the management includes partial splenic embolization (PSE) [1]. A recent multicenter clinical trial confirmed that the combination of endoscopy and radiography-guided partial splenic embolization (X-PSE) provided advantages over conventional endoscopic treatment alone for the prevention of variceal rebleeding in patients with liver cirrhosis [2]. X-PSE requires arterial puncture via the femoral artery and relies on radiographic imaging to guide the catheter, with risks including post-embolization syndrome. In addition, the method is not suitable for patients who are unwilling or unsuitable to undergo radiation, such as pregnant patients or patients planning to conceive.