Chiral Lewis bases (LBs) are versatile nucleophilic organocatalysts that allow for numerous highly enantioselective transformations. Over the last years our group had a strong interest in the utilization of chiral LBs (i.e. isothioureas, phosphines, amines) for the activation and control of simple carboxylic acid derivatives (via in situ C1 ammonium enolate formation) and allenoates (via in situ betaine formation) for numerous applications. In this presentation I will give an overview of our most recent results, presenting past and ongoing investigations focusing on the development and mechanistic understanding of new cyclization reactions as well as new a-functionalization chemistry.
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Mario Waser (2024) studied this question.
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