Pyocele, or neonatal bilateral scrotal abscess, is an uncommon condition in the neonatal period that is brought on by bacterial organisms following bacteremia or retrograde reflux as a result of genitourinary disorders. Usually, the feco-oral pathway is used to disseminate salmonellosis, whether it is typhoidal or not. Although acute gastroenteritis is the most common symptom of Salmonella, extra-intestinal symptoms such as reactive arthritis and osteomyelitis have been reported. This case report details a unique instance of bilateral scrotal abscess caused by neonatal salmonella, the first of its kind to be documented in Ethiopia. No anomalies of the urinary system were found. Cerebrospinal fluid, blood, and urine cultures came out negative.
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