Quantum light-field microscopy for volumetric imaging with extreme depth of field

Light-field microscopy (LFM) extracts volumetric data from a specimen by simultaneously capturing the positional and angular information of light rays emanating from the sample. While conventional LFM requires a compromise between depth of field (DOF) and resolution, this work introduces a quantum approach to eliminate this compromise by harnessing position-momentum entanglement of photon pairs. Compared to conventional LFM at the same resolution, the quantum approach can yield up to tenfold improvement in DOF. This work illustrates the power of utilizing multidimensional entanglement in microscopy and hopefully will inspire further innovations in the field.