Synthesis, Docking Studies And Biological Evaluation Of Thiophene-Oxadiazole Hybrid Derivatives.

The novel thiophene-oxadiazole hybrid derivatives were schemed and substituted, and then they were checked for docking scores against the Human topoisomerase I enzyme. From that, the 10 best docked compounds are selected and synthesized, and spectral data of the synthesized compounds was obtained from IR, 1H NMR, 13C NMR, and mass spectroscopy. Then the ten compounds are subjected to in-vitro cytotoxicity studies by the MTT assay method with the MCF-7 cell line. Among the tested compounds, derivative T11 substituted with a salicylic aldehyde moiety shows a significant IC50 value (45.68 nM) in the tested cell lines and possesses cytotoxic activity