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February 12, 2024ACS Chemical Neuroscience

In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling

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Authors

MTMeng-Hua M. TsaiLCLi ChenMBMichael H. Baumann

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Tsai et al. (2024) studied this question.

synapsesocial.com/papers/68e796dbb6db643587707b81https://doi.org/10.1021/acschemneuro.3c00750
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potency, dissociation kinetics and reversibility of fentanyls and nitazenes by naloxone at the μ opioid receptor2024 · 1 citations
  2. 2A µ-opioid receptor superagonist analgesic with minimal adverse effects2026 · 8 citations
  3. 3Pharmacologic Characterization of Substituted Nitazenes at<i>μ</i>,<i>κ</i>, and<i>Δ</i>Opioid Receptors Suggests High Potential for Toxicity2024 · 40 citations
  4. 4Potency, dissociation kinetics and reversibility of fentanyls and nitazenes by naloxone at the μ opioid receptor2024
  5. 5Coordinated Subpocket Engagement Underlies Nitazene Potency at the μ-Opioid Receptor2026