Facile Preparation of Polysarcosine‐Tethered Inorganic Nanospheres by Using Unimolecular Polypept(o)ides as Template

Polymer‐inorganic nanocomposites that integrate the advantages of both polymers and inorganic nanoparticles (NPs) are broadly exploited for versatile applications. Especially, emerging polymer‐templated preparation of inorganic NPs has drawn extensive attention, which is ascribed to simplified synthesis and feasible tunability. However, how to precisely fabricate biocompatible polymer‐inorganic NPs remains unsolved. In this article, by mild ring opening polymerization (ROP) of β‐benzyl L‐aspartate N ‐carboxyanhydrides (BLA‐NCAs) and sarcosine N ‐carboxyanhydrides (Sar‐NCAs) and subsequent debenzylation, a series of poly(amino acid)‐based unimolecular micelles (PAMAM‐ g ‐(PLA‐ b ‐PSar)) are facilely synthesized. Afterward, by utilization of these star‐like polymers as template, the controllable preparation of various PSar‐tethered inorganic NPs is investigated and characterized meticulously. This general strategy for the preparation of PSar‐tethered inorganic NPs can bring a great chance for future fabrication of biomedical nanoplatforms.