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February 10, 2024European Journal of CancerOpen Access

Isolated melanoma cells in sentinel lymph node in stage IIIA melanoma correlate with a favorable prognosis similar to stage IB

Teresa Amaral Lena Nanz Rudolf Stadler Carola Berking Anja Ulmer Andrea Forschner Andreas Meiwes Frederik Wolfsperger Francisco Meraz-Torres Eftychia Chatziioannou Peter Martus Lukas Flatz Claus Garbe Ulrike Leiter

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Abstract

The American Joint Committee on Cancer 8th edition (AJCC v8) defines sentinel lymph nodes (SLN) containing any tumor cells as positive SLN. Consequently, even thin melanomas with isolated tumor cells (ic) in SLN are classified as stage IIIA, making them candidates for adjuvant therapy.

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Amaral et al. (2024) studied this question.

synapsesocial.com/papers/68e79ac4b6db64358770ab5d https://doi.org/10.1016/j.ejca.2024.113912

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The impairment of CD3+ T lymphocytes in sentinel lymph node of high-risk cutaneous melanoma patients in stage IIB and IICOriginal Research · 2026
2Preoperative and Intraoperative Identification of Sentinel Lymph Nodes in Melanoma Surgery2024 · 4 citations
3Sentinel-Node Biopsy or Nodal Observation in MelanomaPrognostic Study · 2006 · 1,825 citations
4Sentinel lymph node status and oncological outcomes of high-risk and low-risk cutaneous primary melanomaOriginal Research · 2026
5Survival outcomes of stage IIB/IIC cutaneous melanoma treated with wide local excision and adjuvant immunotherapy without sentinel lymph node biopsy.Review · 2026

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