Background: Sex assigned at birth (SAB) is currently used to calculate predicted normative values for oxygen consumption (V O2 ) during cardiopulmonary exercise testing (CPET) in transgender and gender diverse (TGD) patients.It is unclear if this is physiologically valid once gender-affirming hormonal therapy (GAHT) has been instituted.Research Question: What are the changes in functional aerobic capacity (FAC) and in percentage of predicted (%pred) peak V O2 when gender is used, instead of SAB, to estimated normative predicted values among TGD patients >14 years of age who are receiving GAHT?
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Cortes-Puentes et al. (2024) studied this question.
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