Impact of testosterone therapy on pulmonary function in transgender and gender expansive individuals assigned female at birth: A cross-sectional comparative study

Background Interpretation of pulmonary function tests (PFTs) currently uses normative data derived with a cisgender assumption for men and women, not taking into consideration transgender individuals who may have undergone interventions including hormonal therapy. If muscles involved for respiration change with exposure to testosterone therapy, normative PFT calculations for presumed cisgender individuals may not apply to transgender individuals. Thus, investigating pulmonary function in those who have undergone testosterone therapy will aid the accuracy of PFTs for this population.