Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 9, 2024Journal of Pharmacology and Experimental TherapeuticsOpen Access

Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796

View Full Paper
Ask AI
Bookmark
Share

Authors

PTPeter ThorntonVRValérie ReaderZDZsofia Digby

Discussion

Loading...

Member takes

Overview

Key Points

Key points are not available for this paper at this time.

Cite This Study

Thornton et al. (2024) studied this question.

synapsesocial.com/papers/68e79c4cb6db64358770b7ddhttps://doi.org/10.1124/jpet.123.002013
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity2025 · 1 citations
  2. 2Impeding Nucleotide‐Binding Oligomerization Domain‐Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity‐Associated Cardiomyopathy2024 · 6 citations
  3. 3Dietary polyphenols targeting NLRP3 inflammasome in obesity and metabolic disorders: a review on experimental and computational evidence.2026 · 2 citations
  4. 4Enteric glial <scp>NLRP3</scp> inflammasome contributes to gut mucosal barrier alterations in a mouse model of diet‐induced obesity2024 · 3 citations
  5. 5Adipose tissue NLRP3 inflammasome: a therapeutic target in obesity and type 2 diabetes mellitus2025 · 8 citations