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October 9, 2025Frontiers in ImmunologyOpen Access

Lactobacillus plantarum-derived cytoplasmic membrane vesicles as novel anti-inflammatory nanotherapeutics for psoriasis management

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Authors

YXYuedong XieGLGuochao LvJiangnan UniversityDSDandan SuSun Yat-sen University

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Overview

This research reveals that Lactobacillus plantarum-derived cytoplasmic membrane vesicles reduce inflammation in psoriasis, suggesting a new direction for treatment.

Key Points

  • Cytoplasmic membrane vesicles from Lactobacillus plantarum significantly reduce inflammation in psoriasis mouse models.
  • In vitro analysis showed that these vesicles lower the mRNA levels of inflammatory factors in macrophages.
  • Metabolomic profiling identified AEA as a key metabolite contributing to anti-inflammatory effects.
  • These findings highlight the potential of using bacterial vesicles as innovative therapies for managing inflammatory skin diseases.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e10ehttps://doi.org/10.3389/fimmu.2025.1647466
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  4. 4Lactiplantibacillus plantarum IS-10506 Supplementation Improves Clinical Outcome and Immunology Markers in Psoriasis Vulgaris Patients: A Randomized Controlled Trial2024 · 2 citations
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