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October 9, 2025Frontiers in NeurologyOpen Access

Tired minds, normal scores: rethinking cognitive fatigue in multiple sclerosis

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Authors

DSDavide SpinettiIZIgnazio Roberto Zarbo

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Overview

This perspective highlights cognitive fatigue as a distinct dysfunction in multiple sclerosis, indicating a need for new assessment methods and tailored interventions.

Key Points

  • Cognitive fatigue is often undetected in multiple sclerosis, leading to significant disability for patients.
  • Current neuropsychological assessments frequently overlook cognitive fatigue, mistaking it for general fatigue.
  • Integrating prolonged assessment methods could enhance the identification and management of cognitive fatigue.
  • Reframing cognitive fatigue as a clinical target may improve diagnostics and individualized patient care.

Cite This Study

Spinetti et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e119https://doi.org/10.3389/fneur.2025.1664734
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Digital remote monitoring of people with multiple sclerosis2025 · 21 citations
  2. 2Ecological Momentary Assessment2007 · 6,488 citations
  3. 3The Fatigue Scale for Motor and Cognitive Functions (FSMC): validation of a new instrument to assess multiple sclerosis-related fatigue2009 · 614 citations
  4. 4Self-Reported Everyday Memory and Depression in Patients With Multiple Sclerosis2004 · 53 citations
  5. 5Subjective Cognitive Fatigue in Multiple Sclerosis Depends on Task Length2014 · 87 citations