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October 9, 2025Open Access

Comparative analysis of T-cell signatures and astroglial reactivity in Parkinson's pathology across animal models with distinct regenerative capacities

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Comparative study examines T-cell infiltration and astroglial response in Parkinson's disease models, highlighting immune profile differences.

Zebrafish exhibited transient dopaminergic neurodegeneration, supporting regeneration through CD4+ T-cell activity.
MPTP-treated mice displayed permanent neuronal loss and correlated CD8+ T-cell infiltration, indicating reduced survival.
L61 mice had chronic astrogliosis with CD4+ T-cell presence, but without direct links to neuronal loss.
PD brains showed increased CD3+ T-cell infiltration and aSyn aggregation, correlating with dopaminergic degeneration.

Intonti et al. (2025) studied this question.

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October 9, 2025Open Access

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Authors

Comparative study examines T-cell infiltration and astroglial response in Parkinson's disease models, highlighting immune profile differences.

Zebrafish exhibited transient dopaminergic neurodegeneration, supporting regeneration through CD4+ T-cell activity.
MPTP-treated mice displayed permanent neuronal loss and correlated CD8+ T-cell infiltration, indicating reduced survival.
L61 mice had chronic astrogliosis with CD4+ T-cell presence, but without direct links to neuronal loss.
PD brains showed increased CD3+ T-cell infiltration and aSyn aggregation, correlating with dopaminergic degeneration.

Intonti et al. (2025) studied this question.

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