Multivalence Manganese Mediated Dual ROS Generator for Augmented Chemodynamic Therapy and Activated Antitumor Immunogenic Responses

The efficacy of chemodynamic therapy (CDT) and its potential to induce immunogenic cell death (ICD) are highly dependent on the types and efficiency of generated reactive oxygen species (ROS). Herein, we innovatively develop a manganese platinum (MnPt) nanozyme with dual ROS generation for magnetic resonance imaging guided CDT and ICD. The multivalence state of Mn ions authorizes MnPt to simultaneously generate hydroxyl radical and singlet oxygen under high H2O2 and acid condition, which obviously increases the types of ROS. Significantly, the mild photothermal conversion and enzyme-like activity endow MnPt to regulate tumor microenvironment and elevate the operating rate, further increasing the ROS generation efficiency and CDT efficacy in vitro/vivo. Moreover, the exaltation on both types and generation efficiency of ROS significantly enhances immunogenicity and initiates the immune response to limit tumor metastases. This study provides a highly practical strategy for the accurate diagnosis and efficient therapy of tumors.