What question did this study set out to answer?

To develop a multifunctional, self-reinforcing nanoagent capable of delivering Fenton-like manganese ions and depleting antioxidant glutathione to enhance chemodynamic therapy.

February 28, 2018Angewandte Chemie International Edition

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy

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Authors

LLLisen LinFuzhou University JSJibin SongHandan College LSLiang SongChinese Academy of Sciences

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Implication

Experimental study demonstrates enhanced chemodynamic tumor therapy and MRI tracking using manganese dioxide nanoparticles, highlighting a dual ion delivery and antioxidant depletion strategy.

Key Points

To develop a multifunctional, self-reinforcing nanoagent capable of delivering Fenton-like manganese ions and depleting antioxidant glutathione to enhance chemodynamic therapy.
Synthesized mesoporous silica nanoparticles coated with a manganese dioxide shell (MS@MnO2 NPs).
Investigated intracellular uptake, glutathione-mediated reduction of MnO2 to Mn2+, and bicarbonate-dependent hydroxyl radical generation from hydrogen peroxide.
Evaluated glutathione-activated magnetic resonance imaging (MRI) contrast changes and combined chemo-chemodynamic therapeutic action.
Cellular uptake of MS@MnO2 NPs triggered a redox reaction with intracellular glutathione, converting it to glutathione disulfide and efficiently breaking down tumor antioxidant defenses.
The generated Mn2+ ions reacted with hydrogen peroxide in the presence of physiological bicarbonate to produce cytotoxic hydroxyl radicals via Fenton-like chemistry.
MnO2 shell degradation simultaneously produced a glutathione-activated MRI contrast signal, enabling real-time imaging and monitoring of chemo-chemodynamic therapy.

Cite This Study

Lin et al. (2018) studied this question.

synapsesocial.com/papers/6a7ccc8f398814c3397cd0fc https://doi.org/10.1002/anie.201712027

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Implication

Experimental study demonstrates enhanced chemodynamic tumor therapy and MRI tracking using manganese dioxide nanoparticles, highlighting a dual ion delivery and antioxidant depletion strategy.

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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