Supplementary Figures from Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

Zhuxuan Li; Xueqian Zhuang; Chun‐Hao Pan; Yan Yan; Rohit Thummalapalli; Jill Hallin; Stefan Torborg; Anupriya Singhal; Jason C. Chang; Eusebio Manchado; Lukas E. Dow; Rona Yaeger; James G. Christensen; Scott W. Lowe; Charles M. Rudin; Simon Joost; Tuomas Tammela

doi:10.1158/2159-8290.25191507

February 8, 2024Open Access

Supplementary Figures from Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

View Full Paper

Ask AI

Bookmark

Share

Key Points

Alveolar differentiation directly promotes resistance to KRAS inhibition, enabling tumor cell survival in lung adenocarcinoma models during targeted therapy.
Supplementary data compile 7 supplementary figures that document cellular responses, illustrating phenotypic shifts away from lung adenocarcinoma baseline states.
Highlights mechanisms limiting KRAS inhibition efficacy, suggesting that targeting alveolar differentiation pathways may help restore therapeutic sensitivity in lung tumors.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Supplementary analysis reveals alveolar differentiation driving resistance to KRAS inhibition in lung adenocarcinoma, suggesting bypass pathways that limit targeted therapies.

Abstract

It includes 7 supplementary figures for the paper

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Li et al. (2024) studied this question.

synapsesocial.com/papers/68e7b92eb6db64358770f119 https://doi.org/10.1158/2159-8290.25191507

View Full Paper

Ask AI

Bookmark

Share