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October 9, 2025PeerJOpen Access

Quality assessment from biobank plasma and serum specimens: a systematic review

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Authors

XLXiongshun LiangShenzhen Nanshan Center for Chronic Disease ControlWXWanna XuShenzhen Nanshan Center for Chronic Disease ControlLCLin ChenShenzhen Chronic Disease Prevention Center

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Implication

Systematic review evaluates quality factors affecting plasma and serum samples, highlighting preanalytical gaps.

Key Points

  • Temperature significantly affects biomarker stability; non-refrigerated samples show 3.2 times more alterations.
  • Freeze-thaw cycles lead to dose-dependent instability, with over 10 cycles causing 70% of biomarkers to alter.
  • Current quality evaluation methods prioritizing sample processing delays overlook critical preanalytical factors.
  • Standardizing biobanking procedures is necessary to improve sample integrity and ensure research reliability.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/68e7d631bd66d359be6268bahttps://doi.org/10.7717/peerj.20122
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