Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 9, 2025

Navigating the 3D genome at single-cell resolution: techniques, computation, and mechanistic landscapes.

View Full Paper
Ask AI
Bookmark
Share

Authors

FHFeitong HongUniversity of Electronic Science and Technology of ChinaKHKun HanAnhui UniversityYHYuduo HaoUniversity of Electronic Science and Technology of China

Discussion

Loading...

Member takes

Implication

This review highlights advances in single-cell genomics and chromatin architecture, suggesting new therapeutic insights.

Key Points

  • Single-cell 3D genomics reveals chromatin architecture, enhancing understanding of gene regulation and cellular identity.
  • Recent techniques improve genome-wide chromatin contact mapping, linking 3D genome organization to disease progression.
  • Advanced computational frameworks reconstruct dynamic chromatin topologies from high-dimensional data, enabling more precise analyses.
  • These insights support future developments in precision medicine and topology-guided therapeutic strategies.

Cite This Study

Hong et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877bdfhttps://doi.org/10.1093/bib/bbaf520
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sparse regularized joint projection model for identifying associations of non-coding RNAs and human diseases2022 · 20 citations
  2. 2DeDoc2 Identifies and Characterizes the Hierarchy and Dynamics of Chromatin TAD‐Like Domains in the Single Cells2023 · 25 citations
  3. 3SnapHiC-D: a computational pipeline to identify differential chromatin contacts from single-cell Hi-C data2023 · 10 citations
  4. 4Deciphering single-cell 3D chromatin structure using scCTG2024 · 4 citations
  5. 5Subgraph extraction and graph representation learning for single cell Hi-C imputation and clustering2023 · 14 citations