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This is a Experimental Study study.

Modulating Hydrogel Stiffness Through Light‐Based 3D Printing to Mimic Cardiac Fibrosis and Cardiomyocyte Dysfunction Using hiPSC‐Derived Cells

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Activated cardiac fibroblasts can impair cardiomyocyte function in a model mimicking cardiac fibrosis.
Hydrogels with tunable stiffness significantly induce fibroblast activation without TGFβ, outperforming traditional culture methods.
Activated fibroblasts seeded on stiffer hydrogels replicate ECM conditions of native cardiac tissue, highlighting the importance of stiffness.
Combining stiff hydrogels with TGFβ enhances fibroblast activation, mimicking the pathological features associated with cardiac fibrosis.

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Model shows cardiac fibroblast activation on stiff hydrogels in absence of TGFβ, indicating ECM's role in cardiac fibrosis.

Sohn et al. (2025) studied this question.

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