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Effect of Aqueous Extract of Garcinia kola (Bitter Kola) Seed and Its Combination with Ocimum gratissimum (African Basil) Leaves in Diarrhoeal Rats

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This study examines the antidiarrhoea effects of Garcinia kola and Ocimum gratissimum in diarrhoeal rats, suggesting potential therapeutic use.

Aqueous extracts of Garcinia kola and Ocimum gratissimum significantly reduced diarrhoeal symptoms in rats.
The combination of both extracts resulted in a greater anti-motility effect in comparison to individual treatments.
Both extracts were found to be safe for therapeutic purposes based on the acute toxicity (LD50) results.
Castor oil-induced models demonstrated a marked reduction in intestinal content with the extracts, highlighting their antidiarrhoeal activity.

Ezeigwe et al. (2025) studied this question.

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This study examines the antidiarrhoea effects of Garcinia kola and Ocimum gratissimum in diarrhoeal rats, suggesting potential therapeutic use.