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October 9, 2025Circulation Research

Abstract Thu031: MCM2 overexpression in the adult heart promotes cardiac rejuvenation and protection after infarction.

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Authors

PAPerwez AlamKing Saud University

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Implication

Experiment shows MCM2 promotes cardiac rejuvenation and reduces damage in C57/BL6 mice post-infarction, suggesting potential therapeutic pathways.

Key Points

  • Re-expression of MCM2 in the adult heart leads to reduced infarct size and improved cardiac function after myocardial infarction.
  • Inflammatory and fibrotic responses were significantly improved, with angiogenesis pathways activated due to MCM2 overexpression.
  • Utilizing RNA sequencing, MCM2 was identified as essential for cardioprotection linked to inhibition of cell cycle inhibitors Rb1 and Meis2.
  • The findings point to potential therapeutic strategies involving MCM2 for enhancing post-myocardial infarction repair mechanisms.

Cite This Study

Perwez Alam (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877dc1https://doi.org/10.1161/res.137.suppl_1.thu031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MCM2 mediates post-MI cardioprotection by promoting the pro-angiogenic cardiosome signaling2024 · 1 citations
  2. 2Inhibition of Senescence‐Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post–Myocardial Infarction2019 · 73 citations
  3. 3Abstract Thu014: Checkpoint kinase-2 regulates cardiomyocyte cell cycle and ameliorates cardiac function after myocardial infarction2025
  4. 4Exploring cardiomyocytes-endothelial cell communication to promote cardiac revascularization and regeneration2026
  5. 5Exploring the interactions between cardiomyocytes and endothelial cells to induce cardiac revascularization and regeneration2024