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October 9, 2025Circulation Research

Abstract Wed159: Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan-Associated Liver Disease

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Key result

Fontan circulation linked to significant liver metabolic abnormalities, particularly in amino and fatty acid pathways.

  • n=24

Population

Liver samples/biopsies from adolescent patients with Fontan-associated liver disease and age- and…

Design

Case-control

Authors

RSRasheed SuleUniversity of California, DavisPHPo HuChildren's Hospital of PhiladelphiaCSClarissa ShofflerUniversity of Pennsylvania

Discussion

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Implication

Comprehensive multiomic analysis of human Fontan-associated liver disease reveals significant metabolic reprogramming, providing new insights into its fundamental biology and pathogenesis.

Key Points

  • Significant metabolic abnormalities were discovered in the livers of adolescent patients with Fontan circulation, particularly in amino acid metabolism.
  • Results showed that liver metabolic reprogramming contributes to circulatory metabolomic changes in Fontan-associated liver disease.
  • Single-nucleus multiomic RNA sequencing and assays unveiled potential underlying mechanisms of metabolic alterations in FALD.
  • Comparing data with metabolic dysfunction-associated fatty liver disease highlighted dysregulated amino acid metabolism as a common issue.

Study Design

Type

Case-Control (n=24)

Structured PICO

P
Population
24 liver samples from adolescent patients with Fontan-associated liver disease and age- and sex-matched healthy donors.
C
Comparator
Age- and sex-matched healthy donors (n=12)
O
Outcome
Metabolomic landscape and metabolic abnormalitiessurrogate

Comprehensive multiomic analysis of human Fontan-associated liver disease reveals significant metabolic reprogramming, providing new insights into its fundamental biology and pathogenesis.

Cite This Study

Sule et al. (2025) conducted a case-control in Fontan-associated liver disease (n=24). Fontan circulation vs. Healthy donors was evaluated on Metabolic abnormalities. Adolescent patients with Fontan circulation exhibited significant liver metabolic abnormalities, particularly in amino acid and fatty acid metabolism, compared to healthy donors.

synapsesocial.com/papers/68e80eb363e2e2f707877dc7https://doi.org/10.1161/res.137.suppl_1.wed159
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