Effects of Exogenous Melatonin Administration on Psychic Symptoms in Fixed-Shift Workers During Climacteric

Introduction: Menopause is the point at which menstruation permanently ceases, defined by the absence of menstrual periods for 12 consecutive months, typically occurring between the ages of 45 and 55. The climacteric, the period in which menopause takes place, is characterized by hormonal changes, a decline in follicular activity and fertility, as well as alterations in the menstrual cycle. In addition to physical symptoms such as hot flashes and night sweats, this phase is often associated with increased levels of stress, anxiety, and depression, which impact mental health and quality of life. These effects may be exacerbated in shift workers, especially night workers, due to circadian rhythm dysregulation and a possible reduction in endogenous melatonin levels. The objective of this study was to analyze the effects of exogenous melatonin administration on stress, anxiety, and depression symptoms in 46 female workers across different work shifts during the climacteric period.