A Case of a Particular form of Gastric GIST Revealed by Upper Gastrointestinal Bleeding

Gastro Intestinal Stromal Tumors (GISTs) are mesenchymal tumors that develop from the intestinal Cajal cells or their precursors, mainly located in the stomach. They are often asymptomatic but can present clinical signs ranging from abdominal discomfort to upper gastrointestinal bleeding, which requiring practitioners to be aware of their presence. In endoscopy, they are typically covered by mucosa, though ulcerated forms can exist, leading to digestive hemorrhages. Diagnosis is based on histopathological examination coupled with an immunohistochemical study to detect antibodies specific to KIT and DOG-1 proteins, which are present in 95% of cases. Their treatment is surgical, involving resection performed in one block via open surgery or laparoscopic surgery, with tyrosine kinase inhibitors for locally advanced or metastatic GISTs.