What type of study is this?

This is a Human Clinical Trial study.

October 10, 2025DevelopmentOpen Access

DNAH10 interacts with UCHL3-PACRG complex to coordinate sperm head and flagella development during spermiogenesis

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This study demonstrates that DNAH10 deficiency leads to sperm development issues in asthenoteratozoospermia, highlighting UCHL3-PACRG interactions.

Deficiency of DNAH10 results in abnormal sperm head and flagella morphology.
Impaired manchette function and mislocalization of axonemal proteins correlate with DNAH10 dysfunction.
UCHL3 stabilizes PACRG through deubiquitination, with DNAH10 enhancing their interaction.
This research provides insights for genetic diagnosis and prognosis in male infertility cases.

Zheng et al. (2025) studied this question.

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This study demonstrates that DNAH10 deficiency leads to sperm development issues in asthenoteratozoospermia, highlighting UCHL3-PACRG interactions.