Pharmacokinetic profiles of sertraline in pregnancy as a predictor of postpartum depressive symptoms

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Observational study characterizes sertraline pharmacokinetics in pregnancy and their link to postpartum depressive symptoms.

Variability in sertraline pharmacokinetics was noted throughout pregnancy and postpartum, and contributes to depressive symptoms.
Mean 24-hour concentration-to-dose ratios revealed distinct trajectories for sertraline and its metabolite N-desmethylsertraline.
Higher exposure to N-desmethylsertraline correlated with increased scores in multiple depressive symptom scales.
Therapeutic monitoring of sertraline could aid in identifying postpartum depressive symptoms in mothers.

Illamola et al. (2025) studied this question.

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