Research demonstrates a novel cascade reaction enhancing synthesis of polyfluoro compounds, indicating significant utility.
A photocatalyzed-radical cascade reaction for the synthesis of tetrafluoroethylene (–CF2CF2–)-containing benz[e]indene derivatives has been developed. Investigation of the substrate scope reveals that electron-rich arenes accelerate the cascade process. DFT calculations provide insight into the reaction pathway and the role of the additive. Furthermore, application studies demonstrate access to potentially valuable compounds.
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Yasui et al. (2025) studied this question.
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