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August 10, 2026The Journal of Organic Chemistry

Photoredox-CatalyzedRadical Cascade Cyclization withCarboxylic Anhydrides to Access CF2H/CF2Cl-SubstitutedIndolo- and Benzimidazo2,1- a isoquinolin-6(5 H )-Ones

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Authors

PLPingping LiangZhengzhou UniversityTLTianming LiuUniversity of GeorgiaYLYuxuan LiuPeking University

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Implication

Randomized trial demonstrates efficient synthesis of CF2H/CF2Cl-substituted compounds, highlighting innovative catalytic methods.

Key Points

  • The aim is to develop an efficient photoredox-catalyzed cyclization method using radical species derived from carboxylic anhydrides.
  • Utilized commercially available carboxylic anhydrides as fluorinated radical sources.
  • Employs simple acetoxime as the activating reagent.
  • Tests a variety of substrates, demonstrating broad functional-group tolerance.
  • Successfully synthesized over 50 high-value CF2H/CF2Cl-containing indolo- and benzimidazo[2,1-a]isoquinolin-6(5H)-ones.
  • Achieved good yields with challenging C3–H indole substrates.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a7999219c20a9bbd3184c81https://doi.org/10.1021/acs.joc.6c00950
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