Visible-Light-Induced Difluoromethylation/Cyclization of 1-Acryloyl-2-cyanoindoles by [Bis(difluoroacetoxy)iodo]benzene under Catalyst-Free Conditions

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We have developed a visible-light-induced radical cascade difluoromethylation/cyclization reaction of 1-acryloyl-2-cyanoindoles with [bis(difluoroacetoxy)iodo]benzene under catalyst-free conditions. The use of shelf-stable and easily accessible difluoromethylation reagents, combined with environmentally friendly and mild reaction conditions, makes this method an alternative strategy for the synthesis of difluoroalkylated pyrrolo[1,2-a]indolediones.