What question did this study set out to answer?

Develop a visible-light-driven cascade reaction to construct difluoroalkylated indole-fused heterocycles using newly designed aromatic isocyanides.

January 1, 2023Chinese Journal of Organic ChemistryOpen Access

Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides

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Authors

YFYingke Feng HWHe WangHarbin Normal University MCMengxing CuiTongji University

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Implication

Photochemical study demonstrates cascade cyclization of aromatic isocyanides with fluorinated reagents, expanding access to fluorine-modified heterocyclic compounds.

Key Points

Develop a visible-light-driven cascade reaction to construct difluoroalkylated indole-fused heterocycles using newly designed aromatic isocyanides.
Coupled functionalized aromatic isocyanides with commercially available CF2 precursors via visible-light photoredox catalysis under mild reaction conditions.
Engineered a sequential radical addition and cyclization cascade pathway to form seven-membered nitrogen-containing rings.
Synthesized a library of CF2-containing indole-1,2-fused diazepanones via tandem radical addition and cyclization.
Expanded the synthetic reaction profiles and functional utility of substituted aromatic isocyanides under visible-light activation.

Cite This Study

Feng et al. (2023) studied this question.

synapsesocial.com/papers/6a836f85148ed1a081d407dd https://doi.org/10.6023/cjoc202303004

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Implication

Photochemical study demonstrates cascade cyclization of aromatic isocyanides with fluorinated reagents, expanding access to fluorine-modified heterocyclic compounds.

Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides

Discussion

Member takes

Implication

Key Points

Cite This Study

Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides

Discussion

Member takes

Implication

Key Points

Cite This Study

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