This review highlights new biomaterials improving biocompatibility and osseointegration in maxillofacial applications.
Maxillofacial and dental orthopedics is a critical field within dentistry and oral and maxillofacial surgery, aiming to restore normal function and improve patients’ aesthetics. The selection of appropriate biomaterials plays a pivotal role in this domain, as any biological incompatibility or mechanical weakness may lead to serious consequences. Traditional materials such as metals, ceramics, and pure polymers, despite their widespread use, have shown limitations including brittleness, biological incompatibility, and induction of inflammatory responses, highlighting the urgent need for novel biomaterials. These new biomaterials have been developed with the goals of enhancing biocompatibility, increasing bioactivity, and stimulating natural tissue regeneration. Representative examples include modified metals and alloys, bioceramics, biodegradable polymers, and nanocomposites. In particular, nanotechnology has played a crucial role in improving the surface properties of implants, enhancing mechanical strength, and accelerating the process of osseointegration. The clinical applications of these biomaterials range from dental implants and maxillofacial fracture repair to the reconstruction of defects caused by trauma or tumor resection, as well as three-dimensional scaffolds in tissue engineering. Findings from this review indicate that novel biomaterials have successfully addressed many of the shortcomings of traditional materials and have opened new horizons for regenerative treatments in maxillofacial and dental practice. Nevertheless, challenges such as high production costs and the necessity of comprehensive clinical evaluations remain significant obstacles. Overall, this study concludes that the advancement and application of novel biomaterials hold great promise for the future of maxillofacial and dental orthopedics, with the potential to improve treatment outcomes and enhance patients’ quality of life.
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Fatemeh Farahmandi Moghaddam (2025) studied this question.
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