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October 10, 2025Jurnal Farmasi Sains dan PraktisOpen Access

Analysis and Validation of Detection Method for Ethylene and Diethylene Glycol Contaminants in Syrup Using GCMS (Gas Chromatography-Mass Spectrometer)

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Authors

SSSupandi SupandiMMMabrurotul MustafidahSYSiti Yaenap

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Overview

GC-MS reveals EG and DEG contamination in children's syrup drugs, indicating a need for stringent safety measures.

Key Points

  • Detection of ethylene glycol and diethylene glycol contamination was confirmed in syrup samples with concentrations below 0.1%.
  • Validation tests showed high accuracy, with recovery rates between 98% and 101% for the GC-MS method used.
  • The limit of detection for ethylene glycol was 0.26 ng/mg, while diethylene glycol was 0.51 ng/mg.
  • Ensuring reliable detection methods is critical for pharmaceutical safety, highlighting potential public health risks.

Cite This Study

Supandi et al. (2025) studied this question.

synapsesocial.com/papers/68e861a57ef2f04ca37e470bhttps://doi.org/10.31603/pharmacy.v11i2.11180
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and validation of a GC–MS method for the determination of ethylene glycol and diethylene glycol in pharmaceutical syrups2026
  2. 2A Selective Gas Chromatography–Tandem Mass Spectrometry Method for Quantitation of Ethylene and Diethylene Glycol in Paediatric Syrups2024 · 7 citations
  3. 3Ethylene glycol and diethylene glycol impurities determination and assay tests for selected pharmaceutical syrups collected from Addis Ababa, Ethiopia2026
  4. 4B-277 Validation of an Enzymatic Method for Quantification of Ethylene Glycol in Human Serum2025
  5. 5B-325 Evaluation of Ethylene Glycol Stability in Blood and Serum: Impact of Pre-Analytical Conditions and Performance Comparison of an Automated Enzymatic Assay vs. Gas Chromatography-Mass Spectrometry in Clinical Toxicology2025