Chalcogen functionalized pyrimidine synthesis by three-component free radical chalcogenation and pyrimidine ring construction

Key Points

• This method allows efficient synthesis of chalcogen functionalized pyrimidines from simple components.
• Reactions involving enaminones, disulfides, and amidines lead to significant product yields.
• The approach is notable for being transition metal-free, making it more accessible and sustainable.
• Functionalized pyrimidines have various applications, highlighting their importance in organic chemistry and medicinal research.