Direct C–H Alkylation, Acylation, and Silylation of N-heteroarenes Enabled by the Self-Quenching of Quinolinone

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This is a Experimental Study study.

Baoguo Sun; Jianjie Wang; Qian Zhang; Yuanyi Chen; Yan Xu; Xiaohui Zhuang; Chun Lv; Xiao Yang; Weike Su; Can Jin

doi:10.1039/d5gc04299b

January 1, 2025Green Chemistry

Direct C–H Alkylation, Acylation, and Silylation of N-heteroarenes Enabled by the Self-Quenching of Quinolinone

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Key Points

C–H functionalization has significant implications for creating diverse natural products and active compounds.
The approach involved successfully combining alkylation and acylation methods to enhance functionality.
Cross-dehydrogenative coupling was a key technique facilitating the reaction process.
Enabling the self-quenching of quinolinone broadens the scope for N-heteroarenes in chemical synthesis.

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Implication

This research demonstrates C–H functionalization outcomes in N-heterocycles using quinolinone, indicating new pathways for molecule diversification.

Abstract

Direct C–H functionalization of N-heterocycles via C–H/C–H cross-dehydrogenative coupling constitutes a fundamentally significant approach for the late-stage diversification of complex natural products and biologically active molecules. Herein, we report a...

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Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68e865117ef2f04ca37e4c5a https://doi.org/10.1039/d5gc04299b

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Direct C–H Alkylation, Acylation, and Silylation of N-heteroarenes Enabled by the Self-Quenching of Quinolinone

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Direct C–H Alkylation, Acylation, and Silylation of N-heteroarenes Enabled by the Self-Quenching of Quinolinone

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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