This week the ACS announced its intention to establisha "ChemRxiv preprint server to promote early research sharing". This was first tried quite a few years ago, following the example of especially the physicists. As I recollect the experiment lasted about a year, attracted few submissions and even fewer of high quality.
Henry S. Rzepa (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: