Theoretical analysis examines the right-handed twist of alpha-helices in proteins, highlighting Wrinch's 1936 proposal.
Understanding why and how proteins fold continues to be a grand challenge in science. I have described how Wrinch in 1936 made a bold proposal for the mechanism, which however flew in the face of much of then known chemistry.
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Henry S. Rzepa (2011) studied this question.
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