This analysis reveals alkyl-oxygen cleavage mechanisms in ester hydrolysis, suggesting a unique pathway for reaction studies.
My previous dissection of the mechanism for ester hydrolysis dealt with the acyl-oxygen cleavage route (red bond). There is a much rarer alternative: alkyl-oxygen cleavage (green bond) which I now place under the microscope.
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Henry S. Rzepa (2013) studied this question.
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