Background: Muscle-invasive bladder cancer has a poor prognosis. Accurate lymph node (LN) staging is crucial, yet conventional imaging demonstrates limited sensitivity for detecting metastasis, necessitating improved pre-operative assessment. Objectives: To evaluate the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) compared to computed tomography (CT) for LN staging in patients with bladder cancer(BC) undergoing radical cystectomy (RC), and to assess the impact of imaging-determined nodal status on survival outcomes. Methods: This retrospective study analyzed 138 patients who underwent RC and pelvic LN dissection (PLND) at a multisite tertiary institution from 2008 to 2021. All patients received either pre-operative CT or FDG-PET/CT within 8 weeks before RC and PLND. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value for detecting LN metastasis (LNM) were calculated using pathological analysis as the reference standard. KaplanMeier survival analysis and Cox regression were employed to assess overall survival (OS). Results: FDG-PET/CT exhibited higher sensitivity (70% vs. 23.3%) and PPV (70% vs. 38.46%) compared to CT, but lower specificity (78.57% vs. 85.7%). Survival outcomes showed statistically significant differences in OS between node-positive and node-negative groups in the FDG-PET/CT cohort, but not in the CT cohort. Conclusion: FDG-PET/CT provides superior sensitivity and PPV compared to CT for LN staging in BC, facilitating more accurate pre-operative evaluation. The improved prognostic stratification associated with FDG-PET/CT may guide individualized treatment strategies.
Huynh et al. (2025) studied this question.