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This is a Experimental Study study.

October 10, 2025Organic Letters

Nickel-Catalyzed Stereoselective Synthesis of Dihydrobenzofuran Exocyclic Alkenyl Carboxylic Acids from CO₂

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This process generates a range of dihydrobenzofuran carboxylic acids with syn-selectivity.
Gram-scale experiments confirm the method's potential for large-scale applications in synthesis.
Utilizing CO2 as a carbon source makes this approach environmentally friendly and resource-efficient.
The resulting compounds can be further functionalized, expanding their application potential.

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Nickel-catalyzed carboxylation creates exclusive syn-selective alkenyl carboxylic acids, highlighting potential applications.

Ding et al. (2025) studied this question.

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